Assessment of Bcl-xL, TAX, and HBZ gene expression in ATLL patients

by | Aug 11, 2023 | Publications

AIDS Res Hum Retroviruses. 2023 Aug 11. doi: 10.1089/AID.2023.0025. Online ahead of print.


INTRODUCTION: Adult T-cell leukemia/lymphoma is a malignancy with a poor prognosis caused by HTLV-1 infection. TAX and HBZ are two major viral proteins that may be involved in oncogenesis by disrupting apoptosis. Because Bcl-xL plays an integral role in the anti-apoptotic pathway, this study examines the interaction between host apoptosis and oncoproteins.

METHOD AND MATERIAL: We investigated 37 HTLV-1-infected individuals, including 18 asymptomatic and 19 ATLL subjects. mRNA was extracted and converted to cDNA from peripheral blood mononuclear cells (PBMCs), and then gene expression was determined using TaqMan qPCR. Moreover, the HTLV-I proviral load was also measured using a commercial absolute quantification kit (Novin Gene, Iran).

RESULTS: Data analysis revealed that the mean of TAX, HBZ, and PVL was significantly higher among the study groups (ATLL and carriers groups P= (0.003), P= (0.000), and P= (0.002) respectively). There was no statistical difference in Bcl-xL gene expression between studies groups (P=0.323).

CONCLUSION: It is proposed that this anti-apoptotic pathway may not be directly involved in the development of ATLL lymphoma. TAX, HBZ gene expression, and PVL can be utilized as prognostic markers.

PMID:37565279 | DOI:10.1089/AID.2023.0025

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