Zhonghua Nei Ke Za Zhi. 2024 Dec 1;63(12):1196-1204. doi: 10.3760/cma.j.cn112138-20240918-00586.
ABSTRACT
Adult T-cell leukemia/lymphoma (ATL), a rare and unique proliferative tumor of T lymphocytes, is associated with human T-cell leukemia virus type 1 (HTLV-1) infection. Due to its diverse clinical features, multidrug resistance of malignant cells, frequent opportunistic infection, and poor prognosis, ATL remains a clinical challenge. A unified understanding of ATL is currently lacking, and its diagnosis and treatment are not standardized in China due to the small number of cases. Therefore, to strengthen our understanding of ATL, hematology experts have formulated the “Chinese expert consensus on the diagnosis and treatment of adult T-cell leukemia/lymphoma (2024)” based on the latest research progress at home and abroad. This consensus proposes the latest diagnostic and subtype criteria for ATL in China. Furthermore, it briefly describes the infection situation of HTLV-1 in coastal areas of China, the epidemic trends in China, and the latest evidence and recommendations regarding the pathogenesis, clinical manifestations, and treatment strategies, with the aim to standardize the clinical diagnosis and treatment of ATL and ultimately improve the overall survival of patients with ATL.
PMID:39622724 | DOI:10.3760/cma.j.cn112138-20240918-00586
