Could Cesarean Delivery (C-Section) Help Prevent Mother-to-Child Transmission of Human T-lymphocyte Virus Type 1 (HTLV-1)?

by | Jun 30, 2023 | Publications

J Infect Dis. 2023 Jun 30:jiad219. doi: 10.1093/infdis/jiad219. Online ahead of print.


BACKGROUND: Mother-to-child transmission (MTCT) of human T-cell lymphotropic virus type 1 (HTLV-1) is an important route of transmission that can cause lifelong infection. There is high morbidity and mortality due to adult T-cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy (HAM), and other inflammatory disorders. These conditions develop in nearly 10% of people HTLV-1-infected, with a higher risk if infection occurs early in life. Identification of risk factors can inform targeted measures to reduce HTLV-1 MTCT. This study aimed to investigate the potential of cesarean section (C-section) to prevent HTLV-1 MTCT.

METHODS: We performed reviewed of the cases of women and their offspring under regular follow-up at the HTLV-1 outpatient clinic at the Institute of Infectious Diseases Emilio Ribas.

RESULTS: A total of 177 HTLV-1-infected women and 369 adult offspring were investigated. Overall, 15% of the children were positive for HTLV-1 and 85% were negative. Regarding vertical transmission, we found that a breastfeeding duration of >6 months was associated with MTCT. Moreover, maternal proviral load was not associated with transmission, but high educational level and cesarean section were identified as protective factors.

CONCLUSION: HTLV-1 MTCT was associated with mother’s age at delivery of >25 years, low educational level, prolonged breastfeeding, and vaginal delivery.

PMID:37386934 | DOI:10.1093/infdis/jiad219

Other publications you may be interested in…

HTLV-1 Disease

HTLV-1 Disease

HTLV-1 Disease Abstract The years 2020 and 2021 will remain memorable years for many reasons [...]. Click here to...

read more