Diagn Microbiol Infect Dis. 2025 Oct 14;114(2):117149. doi: 10.1016/j.diagmicrobio.2025.117149. Online ahead of print.
ABSTRACT
A case in Peru highlights the challenges of treating cutaneous leishmaniasis, a parasitic disease endemic to the region. A 44-year-old farmer presented with disseminated cutaneous leishmaniasis with mucosal involvement, further complicated by co-infection with HTLV-1, an unusual combination in Peru. Initial treatment with Amphotericin B was interrupted due to neuromuscular symptoms, causing disease recurrence. Serology later confirmed the HTLV-1 co-infection. After a comprehensive regimen including meglumine antimoniate, clindamycin, ceftriaxone, imiquimod, and pentoxifylline, the patient’s lesions fully re-epithelialized within 30 days. The case emphasizes the necessity of treatment adherence and specialized follow-up to manage complex co-infections effectively.
PMID:41108801 | DOI:10.1016/j.diagmicrobio.2025.117149
