HTLV-1-associated demyelinating neuropathy: A case report and review of the literature

by | Mar 9, 2023 | Publications, Uncategorized

eNeurologicalSci. 2023 Feb 20;31:100453. doi: 10.1016/j.ensci.2023.100453. eCollection 2023 Jun.


A 78-year-old man developed paresthesias in the extremities. He was referred to our hospital because of positive anti-human T-cell leukemia virus type 1 (HTLV-1) antibodies in the serum and the presence of abnormal lymphocytes. He was diagnosed as chronic-type adult T-cell leukemia/lymphoma. Neurological examination revealed sensory impairment in the distal parts of the extremities with loss of deep tendon reflexes. Nerve conduction study showed motor and sensory demyelinating polyneuropathy, indicating a diagnosis of HTLV-1-associated demyelinating neuropathy. Corticosteroid therapy followed by intravenous immunoglobulin therapy improved his symptoms. Since demyelinating neuropathy associated with HTLV-1 infection is not well recognized, we here report its characteristics and clinical course through our case report and literature review.

PMID:36891478 | PMC:PMC9986509 | DOI:10.1016/j.ensci.2023.100453

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