HTLV-1-Associated Myelopathy

by | May 20, 2026 | Publications

Brain Nerve. 2026 May;78(5):514-518. doi: 10.11477/mf.188160960780050514.

ABSTRACT

Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) is a neuroimmunological disorder in which the infiltration of HTLV-1-infected T cells into the spinal cord triggers chronic inflammation and neurological damage. HAM predominantly affects the mid-to-lower thoracic cords. Improving long-term outcomes requires accurate assessment of disease activity and timely initiation of therapy. Activity stratification based on cerebrospinal fluid biomarkers is clinically useful.

PMID:42156037 | DOI:10.11477/mf.188160960780050514

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