Microbiol Immunol. 2022 Aug 4. doi: 10.1111/1348-0421.13022. Online ahead of print.
Mannose binding lectin-associated serine protease 2 (MASP2) is the effector part of mannose binding lectin (MBL) that activates the complement system in an antibody-independent manner. We aimed to investigate the role of genetic polymorphisms in the MASP2 gene and susceptibility to HTLV-1 infection. A total of 172 HTLV-1 infected individuals and 170 healthy blood donors were analyzed in this case-control study. Nine single nucleotide polymorphisms (SNPs) encompassing different regions of the MASP2 gene were genotyped with a PCR-SSP assay. The relation between SNPs genotype and susceptibility to HTLV-1 infection was investigated with a chi-squared test considering p<0.05 as statistically significant. Two out of nine tested SNPs were associated with the risk of HTLV-1 infection. The genotype TT at rs17409276 decreased the risk of HTLV-1 (p=0.005, OR=0.301, 95% CI=0.124-0.728). The genotypes CC and CT at rs2273346 were also associated with a higher risk of HTLV-1 acquisition (p=0.004, OR=2.225, 95% CI=1.277-3.877). These findings highlight the importance of MASP2 genetic polymorphisms in the lectin pathway of complement activation and susceptibility to HTLV-1 infection. This article is protected by copyright. All rights reserved.