Primary Effusion Lymphoma-like ATL Developing During Hemodialysis

by | Nov 2, 2022 | Publications

Intern Med. 2022 Oct 19. doi: 10.2169/internalmedicine.9745-22. Online ahead of print.


We herein report a patient with primary effusion lymphoma-like adult T-cell leukemia/lymphoma (PEL-like ATL) that developed during hemodialysis. A 77-year-old man developed a fever and ascites. Elevated levels of LDH, calcium and sIL-2R along with antibodies to HTLV-1 were seen in his blood. Lymphoma cells in ascites were positive for HTLV-1 proviral DNA, but there were no neoplastic cells in peripheral blood or bone marrow and no lymphadenopathy. He was therefore diagnosed with PEL-like ATL, acute-type. After administration of Brentuximab Vedotin, his serum LDH, sIL-2R and atypical cells in ascites cytology decreased. The development of novel effective molecular-targeted therapies is warranted.

PMID:36261387 | DOI:10.2169/internalmedicine.9745-22

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