The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis

by | Oct 12, 2022 | Publications

Rev Inst Med Trop Sao Paulo. 2022 Sep 30;64:e64. doi: 10.1590/S1678-9946202264064. eCollection 2022.


Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.

PMID:36197425 | DOI:10.1590/S1678-9946202264064

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